Title of Talk

Binuclear Metallohydrolases & Biomimetics

 

Abstract

An enhanced understanding of the metal ion binding and active site structural features of phosphoesterases such as the glycerophosphodiesterase from Enterobacter aerogenes (GpdQ), and the organophosphate degrading agent from Agrobacterium radiobacter (OpdA) have important consequences for potential applications.  Coupled with investigations of the metalloenzymes, programs of study to synthesise and characterise model complexes based on these metalloenzymes can add to our understanding of structure and function of the enzymes themselves. This talk will review some of our work and illustrate the significance and contributions of model studies to knowledge in the area.

 

 

Hexamer of GpdQ (left) and active site structure (right). PDB number 3D03

 

References:

1. Daumann, L. J.; Comba, P.; Larrabee, J. A.; Schenk, G.; Stranger, R.; Cavigliasso, G.; Gahan, L.R., Inorg.Chem. 2013, 52, 2029

2. Schenk, G.; Mitic, N.; Gahan, L. R.; Ollis, D. L.; McGeary, R. P.; Guddat, L. W. Acc. Chem. Res. 2012, 45, 1593

3. Daumann, L. J.; Gahan, L. R.; Comba, P.; Schenk, G., Inorg. Chem. 2012, 51, 7669

 

Lawrence R Gahan, Professor

 

School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072 AUSTRALIA

e-mail: gahan@uq.edu.au

Profile. Lawrence Gahan obtained a BSc in chemistry and a PhD from La Trobe University, Melbourne, Australia. After postdoctoral positions in the United States and England he was a research fellow in the Research School of Chemistry at the Australian National University, Canberra, Australia, with Professor Allan Sargeson.  Following a position at Monash University, Melbourne, he moved to the University of Queensland in Brisbane, Australia, in 1984 where he is currently a Professor of Chemistry. His current research focuses on bioinorganic and transition metal chemistry.

 

Selected Publications

1. Daumann, L. J.; Marty, L.; Schenk, G.; Gahan, L. R., Dalton Trans. 2013, 42, 9574

2. Daumann, L. J.; Larrabee, J. A.; Comba, P.; Schenk, G.; Gahan, L.R., Eur. J. Inorg. Chem. 2013, 3082

3. Daumann, L. J.; Comba, P.; Larrabee, J. A.; Schenk, G.; Stranger, R.; Cavigliasso, G.; Gahan, L.R., Synthesis, Inorg. Chem. 2013, 52, 2029

4. Comba, P.; Gahan, L R.; Mereacre, V.; Hanson, G. R.; Powell, A. K.; Schenk, G.; Zajaczkowski-Fischer, M. Inorg. Chem. 2012, 51, 12195  

5. Daumann, L. J.; Gahan, L. R.; Comba, P.; Schenk, G. Inorg. Chem. 2012, 51, 7669.