Prerequisites: CHM 481
Course Contents
Physicochemical Principles of Drug Action; Partition Coefficients; Receptor-Effector Theories; Role of Second Messengers in Drug Action; Methods of Receptor Isolation, Characterization and Modeling (5)
Principles of Drug Design: Random Screening, Analogue Synthesis, Rational Design, Combinatorial Libraries; Enantiopure Drugs and Regulatory Implications; Theoretical Approaches: QSAR, Topliss Tree, MSA, CoMFA (2)
Neuroactive Drugs: Neurons and Neurotransmitters; Brain-related Disorders and Chemotherapy; Drugs Interacting with Cholinergic, Adrenergic, Dopaminergic and Histaminic Receptors and Receptor-subtypes (5)
Anticancer, Antimalarial, Antiviral, and Cardiovascular Drugs; Emerging Trends in Drug Design: Inhibitors of DNA Topoisomerase and Protein Farnesylation & Prenylation; Gene-Based Medicines (8)
Biopharmaceuticals: Recombinant Proteins as Medicines and Vaccines (2)
Drug Delivery: Passive, Assisted and Vector-Based Delivery of Conventional and Genetic Drugs; Tissue-Specific Delivery of Antitumor Agents (8)
Drug Administration, Distribution, Metabolism and Elimination (ADME); Pathways of Drug Metabolism: Enzymology and Molecular Mechanisms; Detoxification of Diverse Drug Classes; Dose Formulation (10)
Induction and Inhibition of Drug Metabolism; Toxicological Aspects of Metabolism: Metabolic Activation of Environmental Carcinogens and DNA Damage; Drug Pharmacokinetics and Final Body Clearance (2)
