Overview

  • Stem cells are at the core of the normal developmental processes and in many pathological conditions. We study both embryonic and adult stem cell fate decisions using the systems biology approach in the context of both normal homeostasis and differentiation of cells in tissue as well as in human diseases. Further, stem cell fate decisions are stochastic in nature. We apply statistical mechanics to study the lineage and differentiation of these cells.


Recent Publications

  • Singh, Raghvendra (2021) "Basal cells in the epidermis and epidermal differentiation" Stem cell Reviews and Reports DOI: 10.1007/s12015-021-10256-1. PDF
  • Raghav Saxena, V B K Sai Phani Kumar Avanigadda, Raghvendra Singh, Vishal Agarwal (2021) "Ab initio dynamics of gas-phase and aqueous-phase hydrolysis of adenosine triphosphate", International Journal of Quantum Chemistry 121(10), e26615 DOI:10.1002/qua.26615
  • Satyam Gupta, Neeraj Koshta, Raghvendra Singh, Goutam Deo (2021) "Flue Gas Treatment via Dry Reforming of Methane", Catalysis for Clean Energy and Environmental Sustainability, Springer
  • Singh R. (2017) "Aberration in NFkB-IkB binding may cause two states of NFkB activity", CURRENT SCIENCE 113(11) DOI:10.18520/cs/v113/i11/2168-2174.
  • Singh R. (2016) "Central role of PI3K - SYK interaction in fibrinogen-induced lamellipodia and filopodia formation in platelets", FEBS Open Bio DOI:10.1002/2211-5463.12149.
  • Singh R (2016) "Model Predicts That MKP1 and TAB1 Regulate p38α Nuclear Pulse and Its Basal Activity Through Positive and Negative Feedback Loops in Repsonse to IL-1", PLoS ONE doi:10.1371/journal.pone.0157572".
  • Singh R (2013) "Signal Oscillation Is Another Reason for Variability in Microarray-Based Gene Expression Quantification", PLoS ONE 8(1): e54753. doi:10.1371/journal.pone.0054753".
  • Gupta S, Singh R (2012) "Analysis of the Virus Dynamics Model Reveals That Early Treatment of HCV Infection May Lead to the Sustained Virological Response", PLoS ONE 7(7): e41209. doi:10.1371/journal.pone.0041209.
  • Singh, R., Nitsche, J.M. and Andreadis, S.T. (2009) "An Integrated Reaction-Transport Model for DNA Surface Hybridization: Implications for DNA Micro arrays", Annals of Biomedical Engineering, 2009 Jan;37(1):255-69.
  • Singh, R., Lei, P., and Andreadis, S. T. (2009). "PKC-delta binds to E-cadherin and mediates EGF induced cell-scattering", Experimental cell research,July, 2009; doi:10.1016/j.yexcr.2009.07.002.
  • Singh, R. and Andreadis, S. T. (2007). "EGF receptor activation decreases retroviral gene transfer through protein kinase C-delta", Molecular Therapy 2007 Feb; 15(2):369-77.