त्वरित संपर्क
धर्मराज आलिमुथु
PhD (IISER-Pune)
Associate Professor, Department of Chemistry
शोध करना दिलचस्पी
- Targeting Ferroptosis in Cancer and Neurodegeneration
- Covalent Probes for Selective Modification of Amino Acids
- Small-Molecule Inducers of Lipid Droplets
- Targeted Protein Degradation: PROTACs & Molecular Glues
SL 206, Southern laboratories
Department of Chemistry
IIT Kanpur,
Kanpur 208016
विशेषज्ञता
Chemical biology, Organic synthesis
Targeted covalent therapeutics
Chemical proteomics
Screening in cancer phenotypes
शिक्षा
Ph.D. (2015) IISER-Pune
M.Sc. (2005) Bharathidasan University
चयनित प्रकाशन
Small molecule promoters of endogenous lipid droplet accumulation drive lysophagy Angew. Chem. Int. Ed., (2025, 202504595)
Tuning isatoic anhydrides’ lysine ligation chemistry for bioconjugation and drug delivery Cell Rep Phys Sci. (2024, 5, 102260)
Redox Modulator Iron Complexes Trigger Intrinsic Apoptosis Pathway in Cancer Cells iScience (2024, 6, 109899)
Diazepam-based covalent modifiers of GPX4 induce ferroptosis in liver cancer cells Chem. Comm. (2024, 60, 1928-1931)
Nitroisobenzofuranone, a small molecule inhibitor of multidrug-resistant Staphylococcus aureus targets peptidoglycan biosynthesis Chem. Comm. (2022, 58, 11669-11672)
Accumulation of 8, 9-unsaturated sterols drives oligodendrocyte formation and remyelination
Nature (2018, 560, 372-376)
Diverse chemical scaffolds enhance oligodendrocyte formation by inhibiting CYP51,
TM7SF2, or EBP, Cell Chem. Biol. (2018)
2-Chloropropionamide as a low-reactivity electrophile for irreversible small-molecule probe identification,
ACS Chem. Biol. (2017, 12, 2124-2131)
Mycobacterium tuberculosishas diminished capacity to counteract redox stress induced by elevated levels of endogenous superoxide,
Free Rad. Biol. Med. (2015, 84, 344-354)
Substituent effects on reactive oxygen species (ROS) generation by hydroquinones,
J. Org. Chem. (2014, 79, 9413-9417)
Arylboronate ester based diazeniumdiolates (BORO/NO), a class of hydrogen peroxide inducible nitric oxide (NO) donors,
Org. Lett. (2014, 16, 2610-2613)
A small molecule for controlled generation of reactive oxygen species (ROS),
Org. Lett. (2014, 16, 398-401)
Design, synthesis and evaluation of small molecule reactive oxygen species generators as selective Mycobacterium tuberculosis inhibitors,
Chem.Commun. (2012, 48, 10325-10327)
पेशेवर अनुभव
Dow Chemical International Private Limited, Pune, 2007-2009
Indian Institute of Science Education and Research-Pune, 2010-2015
Case Western Reserve University-Ohio, 2015-2018
Assistant Professor, Department of Chemistry, Indian Institute of Technology Kanpur, Dec-2018 to June-2025.
Associate Professor, Department of Chemistry, Indian Institute of Technology Kanpur, July 2025 to Present.
वर्तमान शोध
Overview:
We are a chemical biology lab exploring oxidative lipid metabolism to drive lipid droplet accumulation. We pursue ferroptosis as a therapeutic vulnerability in cancer and neurodegeneration. Our work centers on the design of covalent chemical probes and small-molecule modulators that reprogram cellular pathways through precise protein modification. Combining chemical proteomics, mass spectrometry, and mechanism-driven screening, we uncover novel targets, decipher small molecule–protein interactions, and develop first-in-class ferroptosis inducers and inhibitors.
Our goal is to transform chemical tools into next-generation therapeutics through innovation at the chemistry–biology interface.