त्वरित संपर्क
नगमा परवीन
PhD (University of Muenster)
Associate Professor, Department of Chemistry
Room No. 437 ,
Department of Chemistry
IIT Kanpur,
Kanpur 208016
विशेषज्ञता
Viruses, Viral proteins, Bio-mimetic membranes, Lipid nanoparticles (LNPs), mRNA, Fluorescence imaging, single particle imaging and tracking
शिक्षा
PhD (2014) University of Muenster, Muenster, Germany
MSc (2010) Indian Institute of Technology, Chennai, India
BSc (2008) University of Calcutta (Lady Brabourne College), Kolkata, India
शिक्षण क्षेत्र
Physical Chemistry
Molecular Biophysics
Spectroscopy and Imaging
चयनित प्रकाशन
Protease Mediated Shedding and Intermittent Mobility of SARS-CoV-2 Delta Variant; Manorama Dey, Poojitha Potharaju, Khushika, Krishnan Harshan, Pritam Kumar Jana*, and Nagma Parveen*; Journal of Physical Chemistry Letters, 2026, 17, 1, 325–333 https://doi.org/10.1021/acs.jpclett.5c02783
Helper Lipids Accelerate the Mass Transfer of Cationic Lipid Nanoparticles Resulting in an Efficient Gene Delivery, Anurag Sharma, Khushika, Monika Chaudhary, Pritam Kumar Jana, and Nagma Parveen*; Nanoscale, 2026, 18, 1420-1432. https://doi.org/10.1039/D5NR03142G
SARS-CoV-2 Evolved Variants Bind to Sialylated Gangliosides and Are Inhibited by Tetravalent Sialo-Glycocluster; Geetanjali Negi, Vinay Kumar Pandey, Poojitha Potharaju, Manoj K. Jaiswal, Krishnan H. Harshan*, Vinod K. Tiwari*, and Nagma Parveen*, ACS Infectious Diseases, 2025, 11, 3036–3049, https://doi.org/10.1021/acsinfecdis.5c00143
Synergistic Binding of SARS-CoV-2 to ACE2 and Gangliosides in Native Lipid Membranes, Manorama Dey, Anurag Sharma#, Garvita Dhanawat#, Divya Gupta, Krishnan H. Harshan, and Nagma Parveen*, 2024, ACS Infectious
Diseases, 10, 907-916 https://doi.org/10.1021/acsinfecdis.3c00519
Disruption Mechanisms of Enveloped Viruses by Ionic and Non-Ionic Surfactants, Geetanjali Negi, Anurag Sharma, Monika Chaudhary, and Nagma Parveen*, 2024, Journal of Physical Chemistry B, 128, 768-780, https://doi.org/10.1021/acs.jpcb.3c05531
Particle-based phasor-FLIM-FRET resolves protein-protein interactions inside single viral particles, Quinten Coucke#, Nagma Parveen#, Guillermo Solís Fernández, Chen Qian, Johan Hofkens, Zeger Debyser, Jelle Hendrix, 2023, Biophysical Reports, 3, 100122, https://doi.org/10.1016/j.bpr.2023.100122
Giant Plasma Membrane Vesicles as Cellular-Mimics for Probing SARS-CoV-2 Binding at Single Particle Level, Manorama Dey#, Garvita Dhanawat#, Divya Gupta, Ayush Goel, Krishnan H. Harshan, and Nagma Parveen*, 2023, ChemistrySelect, 8, e202302608 https://doi.org/10.1002/slct.202302608
SARS-CoV-2 Binding to Terminal Sialic Acid of Gangliosides Embedded in Lipid Membranes, Geetanjali Negi#, Anurag Sharma#, Monika Chaudhary, Divya Gupta, Krishnan H. Harshan, and Nagma Parveen*, 2023, ACS Infectious Diseases, 9, 1346–1361, https://doi.org/10.1021/acsinfecdis.3c00106
Parveen N.*, Rydell G., Larsson G., Hytonen V., Zhdanov V., Hook F.* and Block S.*, “Competition for Membrane Receptors: Norovirus Detachment via Lectin Attachment” J. Am. Chem. Soc. 2019, 141(41), 16303-16311, doi.org/10.1021/jacs.9b06036
Parveen N., Rimkute I., Block S., Rydell G., Midtvedt D., Larsson G., Hytonen V., Zhdanov V., Lundgren A., and Hook F., “Membrane Deformation Induces Clustering of Norovirus Bound to Glycosphingolipids in a Supported Cell-Membrane Mimic”, J. Phys. Chem. Lett., 2018, 9(9), 2278-2284, DOI: 10.1021/acs.jpclett.8b00433
Parveen N., Block S., Zhdanov V., Rydell G. and Hook F., “Detachment of Membrane Bound Virions by Competitive Ligand-Binding Induced Receptor Depletion”, Langmuir ACS Editor’s Choice, 2017, 33 (16), 4049-4056 DOI: 10.1021/acs.langmuir.6b04582
Zetterberg M., Ahlgren S., Hernandez V., Parveen N. and Edwards K., “Optimization of Lipodisk Properties by Modification of the Extent and Density of the PEG Corona”, J. Colloid Interface Sci., 2016, 484, 86-96 DOI: jcis.2016.08.067
Parveen N.*, Jana K. P., and Schoenhoff M.*, “Viscoelastic Properties of Polyelectrolyte Multilayers Swollen with Ionic Liquid Solutions” Polymers, 2019, 11(8), 1285,
Parveen N. and Schoenhoff M., “Swelling and Stability of Polyelectrolyte Multilayers in Ionic Liquid Solution”, Macromolecules, 2013, 6 (19), 7880-7888, DOI: 10.1021/ma401625r
पेशेवर अनुभव
Assistant Professor, IIT Kanpur, February 2020
Postdoctoral Researcher, University of Leuven, Belgium, 2017-2019
Postdoctoral Researcher, Chalmers University of Technology, Sweden, 2014-2017
वर्तमान शोध
We study functional biological nanoparticles that encapsulate nucleic acids. These include natural systems, such as viruses, as well as engineered platforms designed for nucleic acid delivery, such as lipid nanoparticles (LNPs).
Our focus is on understanding their molecular interactions at the membrane interface and how these interactions govern key biological outcomes—namely, cellular infection in the case of viruses and gene delivery in the case of LNPs.
Insights from these studies are critical for translational applications, including the rational development of antiviral therapeutics, the design of safer vaccine candidates, and the advancement of effective gene therapy strategies.