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IITK
Nagma Parveen

Nagma Parveen

PhD (University of Muenster)

Associate Professor, Department of Chemistry

Specialization

Viruses, Viral proteins, Bio-mimetic membranes, Lipid nanoparticles (LNPs), mRNA, Fluorescence imaging, single particle imaging and tracking

Education

PhD (2014) University of Muenster, Muenster, Germany

MSc (2010) Indian Institute of Technology, Chennai, India

BSc (2008) University of Calcutta (Lady Brabourne College), Kolkata, India

Teaching Area

Physical Chemistry

Molecular Biophysics

Spectroscopy and Imaging

Selected Publications

Protease Mediated Shedding and Intermittent Mobility of SARS-CoV-2 Delta Variant; Manorama Dey, Poojitha Potharaju, Khushika, Krishnan Harshan, Pritam Kumar Jana*, and Nagma Parveen*; Journal of Physical Chemistry Letters, 2026, 17, 1, 325–333 https://doi.org/10.1021/acs.jpclett.5c02783

Helper Lipids Accelerate the Mass Transfer of Cationic Lipid Nanoparticles Resulting in an Efficient Gene Delivery, Anurag Sharma, Khushika, Monika Chaudhary, Pritam Kumar Jana, and Nagma Parveen*; Nanoscale, 2026, 18, 1420-1432. https://doi.org/10.1039/D5NR03142G

SARS-CoV-2 Evolved Variants Bind to Sialylated Gangliosides and Are Inhibited by Tetravalent Sialo-Glycocluster; Geetanjali Negi, Vinay Kumar Pandey, Poojitha Potharaju, Manoj K. Jaiswal, Krishnan H. Harshan*, Vinod K. Tiwari*, and Nagma Parveen*, ACS Infectious Diseases, 2025, 11, 3036–3049, https://doi.org/10.1021/acsinfecdis.5c00143

Synergistic Binding of SARS-CoV-2 to ACE2 and Gangliosides in Native Lipid Membranes, Manorama Dey, Anurag Sharma#, Garvita Dhanawat#, Divya Gupta, Krishnan H. Harshan, and Nagma Parveen*, 2024, ACS Infectious
Diseases, 10, 907-916 https://doi.org/10.1021/acsinfecdis.3c00519

Disruption Mechanisms of Enveloped Viruses by Ionic and Non-Ionic Surfactants, Geetanjali Negi, Anurag Sharma, Monika Chaudhary, and Nagma Parveen*, 2024, Journal of Physical Chemistry B, 128, 768-780, https://doi.org/10.1021/acs.jpcb.3c05531

Particle-based phasor-FLIM-FRET resolves protein-protein interactions inside single viral particles, Quinten Coucke#, Nagma Parveen#, Guillermo Solís Fernández, Chen Qian, Johan Hofkens, Zeger Debyser, Jelle Hendrix, 2023, Biophysical Reports, 3, 100122, https://doi.org/10.1016/j.bpr.2023.100122

Giant Plasma Membrane Vesicles as Cellular-Mimics for Probing SARS-CoV-2 Binding at Single Particle Level, Manorama Dey#, Garvita Dhanawat#, Divya Gupta, Ayush Goel, Krishnan H. Harshan, and Nagma Parveen*, 2023, ChemistrySelect, 8, e202302608 https://doi.org/10.1002/slct.202302608

SARS-CoV-2 Binding to Terminal Sialic Acid of Gangliosides Embedded in Lipid Membranes, Geetanjali Negi#, Anurag Sharma#, Monika Chaudhary, Divya Gupta, Krishnan H. Harshan, and Nagma Parveen*, 2023, ACS Infectious Diseases, 9, 1346–1361, https://doi.org/10.1021/acsinfecdis.3c00106

Parveen N.*, Rydell G., Larsson G., Hytonen V., Zhdanov V., Hook F.* and Block S.*, “Competition for Membrane Receptors: Norovirus Detachment via Lectin Attachment” J. Am. Chem. Soc. 2019, 141(41), 16303-16311, doi.org/10.1021/jacs.9b06036

Parveen N., Rimkute I., Block S., Rydell G., Midtvedt D., Larsson G., Hytonen V., Zhdanov V., Lundgren A., and Hook F., “Membrane Deformation Induces Clustering of Norovirus Bound to Glycosphingolipids in a Supported Cell-Membrane Mimic”, J. Phys. Chem. Lett., 2018, 9(9), 2278-2284, DOI: 10.1021/acs.jpclett.8b00433

Parveen N., Block S., Zhdanov V., Rydell G. and Hook F., “Detachment of Membrane Bound Virions by Competitive Ligand-Binding Induced Receptor Depletion”, Langmuir ACS Editor’s Choice, 2017, 33 (16), 4049-4056 DOI: 10.1021/acs.langmuir.6b04582

Zetterberg M., Ahlgren S., Hernandez V., Parveen N. and Edwards K., “Optimization of Lipodisk Properties by Modification of the Extent and Density of the PEG Corona”, J. Colloid Interface Sci., 2016, 484, 86-96 DOI: jcis.2016.08.067

Parveen N.*, Jana K. P., and Schoenhoff M.*, “Viscoelastic Properties of Polyelectrolyte Multilayers Swollen with Ionic Liquid Solutions” Polymers, 2019, 11(8), 1285, 

https://doi.org/10.3390/polym11081285

Parveen N. and Schoenhoff M., “Swelling and Stability of Polyelectrolyte Multilayers in Ionic Liquid Solution”, Macromolecules, 2013, 6 (19), 7880-7888, DOI: 10.1021/ma401625r

Professional Experience

Assistant Professor, IIT Kanpur, February 2020

Postdoctoral Researcher, University of Leuven, Belgium, 2017-2019

Postdoctoral Researcher, Chalmers University of Technology, Sweden, 2014-2017

Current Research

We study functional biological nanoparticles that encapsulate nucleic acids. These include natural systems, such as viruses, as well as engineered platforms designed for nucleic acid delivery, such as lipid nanoparticles (LNPs).

Our focus is on understanding their molecular interactions at the membrane interface and how these interactions govern key biological outcomes—namely, cellular infection in the case of viruses and gene delivery in the case of LNPs.

Insights from these studies are critical for translational applications, including the rational development of antiviral therapeutics, the design of safer vaccine candidates, and the advancement of effective gene therapy strategies.