Dr. Sivaprakash Ramalingam obtained his PhD from the University of Madras. He received his Post-doctoral training in genome-editing at Johns Hopkins University, Baltimore, USA. He was a recipient of the Maryland Stem Cell Research Fund (MSCRF) Post-doctoral Fellowship and worked at JHU. He served as a Principal Scientist at the CSIR-Institute of Genomics and Integrative Biology, New Delhi, before joining the BSBE department at IIT Kanpur.

Dr. Ramalingam’s group is primarily focused on genomics and molecular medicine. We employ advanced genome engineering techniques to manipulate genome sequence, allowing us to uncover the molecular mechanisms behind a broad spectrum of genetic disorders and malignancies. His lab is also dedicated to developing innovative therapeutic strategies for various pathogenic conditions.

The main research interests are:

• Development of pathophysiologically relevant cellular models (including patient-derived iPSCs) to study disease biology and drug discovery
• Elucidating the regulatory landscape of fetal hemoglobin in β-globin gene cluster for disease intervention.
• High throughput screening and identification of pharmacological small molecules for treating various genetic disorders.
• Deciphering the molecular mechanisms of antigen heterogeneity in B-cell malignancies
• Development of engineered immune cells for various malignancies