Objectives

Broad objectives of this proposal

  1. (a) To develop a state-of-the-art facility to fabricate the printable prototype biosensors which can enhance the research and development activities in the areas of soft micro-nanofabrication.
  2. (b) To develop a non-invasive alternative to body fluid (serum, saliva, urine) testing, for diagnosis and prognosis predicting stages of cancer.
  3. (c) To test emerging and potent cancer biomarkers for pancreatic, ovarian and oral cancer.
  4. (d) To conduct workshops/training to research students in the field of nanofabrication.
  5. (e) To provide state of the art fabrication/characterization facility to research students from different parts of the country.

Timeline

S.N. Activity to be undertaken Timeline Indicators of progress / milestone
1 1) Procurement of analytical tools.
2) Procurement of consumables and setting up facilities for research activities in the proposed areas. 		1 – 6 months a. Installation and experiments with standard test samples.
b. Identification of biomarkers for pancreatic cancer.
c. Identification of biomarkers for ovarian cancer.
d. Identification of biomarkers for oral cancer.
6 – 12 months e. Biomarker selection for pancreatic, ovarian, and oral cancer.
f. First design of sensor device and material selection.
g. First experiments with energy, materials, thin films.
2 1) Intense research activities in the proposed area.
2) Call of proposals for microfluidic device development.
3) Workshops for academic & non-academic institutes around Kanpur. 		12 – 18 months h. Synthesis of nanoparticles & surface modification.
i. Development of recognition element.
j. Microfluidic device design.
k. Website announcement & accepting external samples.
18 – 24 months l. First phase testing of materials.
m. Implement signal amplification strategies.
24 – 30 months n. Design microfluidic device for specific biomarkers.
30 – 36 months o. Microfluidic device fabrication in process.
3 Calibration of sensors using biomarker standards & reliability testing. 36 – 42 months q. Benchmarking with existing technologies.
r. Evaluate performance with standards.
s. Collection of human samples.
42 – 48 months v. Validation with patient-derived samples.
4 Fabrication of biosensor prototypes & project report writing. 48 – 60 months x. Prototype demonstration, patents, publications.
y. Quality control measures established.