Hindi Version | IIT Kanpur

Prerequisites:

CHM 342/442

Course Contents

Inorganic Heterocyclic Rings
P-N rings: Cyclophosphazenes and Cyclophosphazanes. Synthesis, structure and reactivity. Bonding models
P-N-X rings: carbophosphazenes, thiophosphazenes, metallaphosphazenes
Si-O rings: Cyclosiloxanes
Sn-O rings: Stannoxanes
B-containing rings: Boranes, carboranes, metallacarboranes, Borazine
Al-containing Rings: Al-N rings and cages, Al-C rings and cages, Alumoxanes (20 lectures)

Inorganic Homocyclic Rings
Inorganic homocyclic rings and cages containing silicon, germanium , boron, aluminum and gallium (5 lectures)

Inorganic Macrocycles
Metalla porphyrins (5 lectures)

Inorganic polymers
A brief review of organic polymers-methods of synthesis, polymer characteristics-molecular weights, glass-transition temperatures, stress-strain characteristics etc.
Polyphosphazenes, polysiloxanes, polysilanes, organometallic polymers. Synthetic methods, structure-property relationships, applications. (12 lectures)

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Most of the material for this course will be accessed from primary literature viz., Journal articles. Some text books that will be followed are as follows:
Inorganic and Organometallic Polymers. Chandrasekhar, V. Springer-Verlag, Heidelberg, 2005.
Contemporary Polymer Chemistry. 3rd Edn. Allcock H.R.; , Lampe, F.W.; Mark, J. Prentice Hall, N, 2004.
Inorganic Polymers. Mark, J.E.; West, R.; Allcock, H.R.; Prentice-Hall, NY, 1992.
Synthetic Metal Containing Polymers. Manners, I. Wiley-VCH, Weinheim, 2004.

Orbital Interactions in Chemistry

CHM645

3-0-0-9

Courses with significant overlap with this course:

Semester of last offering:

Date of approval: dd-mmm-yyyy

Prerequisites:

CHM442

Course Contents

Molecular Symmetry in Chemistry
Symmetry – Introduction, Symmetry operations & elements, Groups,
Representations and character tables, Reduction of reducible representations,
Group-Subgroup relationships: Descent and ascent in symmetry. Degeneracies,
Direct products. Symmetry properties of Orbitals, Symmetry adapted
wavefunctions. (10 lecture)

Molecular orbital construction
H2, linear and angular H3, Linear, rectangular, square planar and tetrahedral H4,
pentagonal H5 and hexagonal H6.
Diatomic molecules A-A and A-B. Electronegativity perturbation.
Ligands with _-systems.
AH2, AH3, AH4, AH5 and AH6. Walsh diagram. (10 lectures)

Symmetry aspects of the d-orbital splitting by ligands.
Symmetry adapted orbitals on the ligands: s-interactions.
MH6 (Oh), MH5 (D3h and C4v), MH4 (D4h and C4v), MH3 (D3h and C2v).
Correlation.
Inclusion of p-orbitals: ML6
P-donor and P-acceptor ligands: MCl6 and M(CO)6 (10 lectures)

4. Applications:
Isolobal analogy, The Woodward-Hoffmann Rules – pericyclic reactions, Zeise's salt,
Metal carbonyls, Kubas complex W(CO)3(PCy3)2(H2), Agostic complex, Oxidative
addition and reductive elimination, Migratory insertion and b-hydride elimination,
Metal-Carbene complexes (Fischer, Schrock and N-heterocyclic carbene), Bimetallic
complexes: from Single to Quadruple/Quintuple bond, Magnetic interactions,.
(12 lectures)

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‘Orbital Interactions in Chemistry’ - Wiley-Interscience, 1st and 2nd Edition - Thomas A. Albright,
Jeremy K. Burdett and Myung-Hwan Whangbo
‘Molecular Orbitals of Transition Metal Complexes’ Oxford University Press - Yves Jean
‘Molecular Symmetry and Group Theory’ Wiley and Sons - Robert L. Carter
Chemical Applications of Group Theory, 3rd Edition – F. A. Cotton

Chemical Kinetics

CHM622A

3-0-0-9

Courses with significant overlap with this course:

Semester of last offering:

Date of approval: dd-mmm-yyyy

Prerequisites:

Course Contents

Phenomenological kinetics: Simple and complex systems including opposing, concurrent and consecutive reactions

Rate law and mechanism, relation with thermodynamics

Precision in rate measurement, data analysis

Special experimental methods including flash photolysis, shock tube, molecular beam and relaxation techniques

Oscillatory reactions

Theories of reaction rates: bimolecular reactions, rate coefficient, activation energy, potential energy surfaces, trajectory methods and transition state theory. Unimolecular and termolecular reactions

Applications: photochemistry, solution kinetics, homogeneous and heterogeneous catalysis and enzyme kinetics

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K. J.Laidler, Chemical Kinetics, 3rd Ed. Harper & Row, New York, 1987
R. D. Levine and R. B. Bernstein, Molecular Reaction Dynamics and Chemical Reactivity, Oxford Univ. Press, Oxford, 1987
J. I. Steinfeld, J. S. Francisco, W. L. Hase, Chemical Kinetics and Dynamics, 2nd ed. Prentice-Hall, NJ 1999.

Enzyme- reactions mechanism and kinetics

CHM632

3-0-0 (9)

Courses with significant overlap with this course:

Semester of last offering:

Date of approval: dd-mmm-yyyy

Prerequisites:

CHM 481

Course Contents:

Enzyme kinetics of single and multiple substrate systems including Enzyme assays and inhibition
(15 lectures)

Cooperativity and multienzyme systems (4 lectures)

Enzyme structure and identification of active site residues labelin, chemical modification and mutagenesis
(6 lectures)

Enzyme Mechanisms – Methods of study and mechanisms of some enzymes like
Serine proteases, polymerases, ribonucleases, lysozyme and ribonucleotide reductases (radical enzyme)
(15 lectures)

Mechanism based enzyme inhibition and drugs –5-fluorouracil for thymidylate synthase
(2 lectures)

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Allan Ferhst, Structure and Mechanism in Protein Science: A Guide to Enzyme Catalysis and Protein Folding.
N. C. Price and E. Stevens, Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins.
I. H. Segel, Biochemical calculations, How to Solve Mathematical Problems in General Biochemistry, 2nd Edition.

Organic Photochemistry

CHM614A

3-0-0-9

Courses with significant overlap with this course:

Semester of last offering:

Date of approval: dd-mmm-yyyy

Prerequisites: CHM402 or equivalent

Course Contents

An overview of basic concepts of photochemistry

Energy transfer; theoretical aspects of organic photochemistry; reaction mechanisms; photoreduction and photosubstitution reactions; photocycloadditions; photoisomerizations; photofragmentation and elimination reactions; photolytic deprotection and activation of functional groups.

Singlet oxygen: generation and reactions; photoinduced electron transferbasic concepts, illustrative examples of application to organic synthesis; photochemistry in organized media. Nanosecond and picoseconds studies of organic photoreactions.

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