Organic Chemistry I




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Course Contents

Stereochemistry, Dynamic stereochemistry, Mechanistic and Stereo chemical aspects, Reactive Intermediates: Carbenes, Nitrenes, Radicals, Carbocations.

Mechanistic and Stereochemical Aspects of: (10) Baeyer-Villiger, Claisen (including Johnson-Claisen, Ireland-Claisen, Eschenomser, Overman modifications) Cope, and oxy-Cope, Wittig rearrangements (both 1,2 and 2,3 Wittig rearrangements); ene and metalloene reactions; (2+2), (3+2) and (4+2) cycloadditions; Barton reaction.

Organometallic Chemistry: (5) Mechanism and stereochemistry of various reactions. Palladium based reactions such as Heck, Stille, Suzuki, Sonogashira, Buchwald-Hartwig couplings; Tsuji-Trost C-C bond formations; Ni and Sn catlysed reactions.

Enzymatic Reactions: (3) Mecahnistic and stereochemical aspects of hydrolases (including esterases and lipases), oxido-reductases.

Green Chemistry: Concepts and applications (3)

Classification and Structures of some natural products such as terpenoids, steroids, alkaloids and prostaglandins (5) 



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  • March, J., Advanced Organic Chemistry, 4th ed, 1999.

  • Nasipuri, D., Stereochemistry of Organic Compounds, 2nd ed., 1995.

  • Solomons, T. W. G., Organic Chemistry 6th ed, 1996.   

  • Sykes, Peter, A guide book to Mechanism in Organic Chemistry.

  • R. Bruckner, Advanced Organic Chemistry, 2002

  • R. Bruckner, Organic Mechanisms, 2010

  • M. B. Smith, Organic Synthesis, 3rd Ed. 2010

  • Clayden, Greeves, Warren, and Wothers, Organic Chemistry, 1st ed, 2001



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