CHM681A

3-0-0-9

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Prerequisites: CHM 481

Course Contents

Recombinant DNA techniques, Protein folding, design and Engineering, Chou-Fasman rules, Ramachandran plot and conformation of biopolymers. Mechanisms of important enzymes. Biosynthesis of nucleic acids and proteins. confactors. (12)
Immunology. Immune response, Innate immunity and adaptive immunity, Immune dysfunction and its consequences, Immunogenicity, antigens, antibody diversity, monoclonal antibodies, autoimmunity, Hybridoma technology (15)
Biosynthesis of lipids and fatty acids. Secondary metabolism, Membrane transport, Amino acid biosynthesis and metabolism. (6)
Cell differenciation, Regulation of gene expression, recombination, DNA replication, signal transduction. (8)

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Fundamentals of Biochemistry by Voet, Voet and Pratt
Biochemistry by L. Stryer, Proteins by T.E. Creighton, Genes VII by B. Lewin, Introduction to protein structure by Branden and Tooze, Enzyme structure and Mechanism by Alan Fersht.