Professor, Department of Biological Sciences & Bioengineering (BSBE)
Specialization
Gene therapy, Human molecular genetics
Research Interest
Our research program is focused on developing a state-of-art molecular medicine platform to address the unmet clinical needs for several monogenic human diseases (haemophilia, retinal degeneration) and cancers (hepatocellular carcinoma, leukaemia). To achieve this, we interface at the basic biology of a virus (AAV) and its translational science; utilizing a variety of molecular, cellular and preclinical models.
Education
Post-doctoral Fellow- 2007-2009, Powell Gene Therapy Center, University of Florida, Gainesville, USA.
PhD [Biomedical sciences/ Molecular Biology]-2008, Christian Medical College, Vellore, India.
Mary B, Maurya S, Kumar M, Bammidi S, Kumar V, Jayandharan GR*. Molecular engineering of Adeno-associated virus capsid improves its therapeutic gene transfer in murine models of hemophilia and retinal degeneration. Molecular Pharmaceutics 2019, 16:4738-4750.
Maurya S, Mary B, Jayandharan GR*. Rational engineering and evaluation of Neddylation and SUMOylation site modified AAV vectors in murine models of hemophilia B and Leber congenital amarousis. Hum Gene Ther 2019, doi:10.1089/hum.2019.164
Khan N, Bammidi, S, Jayandharan, GR*. A CD33 antigen targeted AAV6 vector expressing an inducible caspase-9 suicide gene is therapeutic in a xenotransplantation model of acute myeloid leukemia. Bioconjugate Chem. 2019, 30:2404-2416.
Mary B, Maurya S, Arumugam S, Kumar V, Jayandharan GR. Post-translational modifications in capsid proteins of recombinant adeno-associated virus (AAV) 1-rh10 serotypes. FEBS J. 2019, 286:4964-4981.