Saravanan Matheshwaran

PhD (IISc Bangalore)

Assistant Professor, Department of Biological Sciences & Bioengineering (BSBE)


Research Interest



  • Ph.D, Indian Institute of Science, Bangalore(2008)
    Thesis title: New Active Site Fold And The Role Of Metal Ions In Structure Function Relationship Of A Promiscuous Endonuclease - R.KpnI
    Thesis supervisor: Prof. Valakunja Nagaraja
  • M.Sc., Madurai Kamaraj University, Madurai (2001)
  • B.Sc., University of Madras (1999)



  • Biochemistry, Molecular Biology, Microbiology and Immunology

  • Modern Instrumental Methods in Biological Sciences Biochemistry

  • Saravanan M, Vasu K and Nagaraja V. Evolution of sequence specificity in a restriction endonuclease. (2008) Proc Natl Acad Sci USA. 105:10344-10347.

  • Saravanan M, Wuerges J, Bose D, Cook N, Zhang X and Wigley DB. Interactions between the nucleosome histone core and Arp8 in the INO80 Chromatin Remodelling Complex. (2012) Proc Natl Acad Sci USA. 109:20883-20888.

  • Saravanan M, Vasu K, Ghosh S and Nagaraja V (2007)Two distinct roles for Zn2+ in maintaining structural integrity and induce DNA sequence specificity in a promiscuous endonuclease J. Biol. Chem. 282: 32320-32326.

  • Saravanan M, Vasu K, Kanakaraj R, Rao D N and Nagaraja V (2007) DNA binding and kinetics with R.KpnI reveal lower degree of discrimination at non-canonical sequences Nucleic Acids Res. 35: 2777-2786

  • Saravanan M, Bujnicki J.M, Cymerman I.A, Rao D.N. and Nagaraja V. (2004) Type II restriction endonuclease R.KpnI is a member of the HNH nuclease superfamily. Nucleic Acids Res. 32: 6129-6135.


Graduate Students
1. Mr. Bhupender Verma
2. Ms. Shuchi Arora
3. Mr. Shantanu Sen
4. Ms. Prerana Singh
5. Mr. Quazi Tausif Ahmed

Master Students
1. Megha Jhanji
2. Vasvi Tripati
3. Monika Sharma

  • January-February 2008 – Visiting Scientist, ASIA LINK programme on 'Human resources Development in the Study of Nucleic Acids' Institute for Biochemistry, JL University, Giessen, Germany

  • April 2008 – September 2010: Prof. Dale Wigley' s group, CRUK Postdoctoral Fellow, EMBO fellow, Clare Hall Labs, London Research Institute, Cancer Research UK, Potters Bar, UK

  • October 2010 – February 2012: Prof. Dale Wigley' s group, EMBO fellow, The Institute of Cancer Research, London, UK

  • April 2012- November 2012: EMBL Interdisciplinary Postdoctoral Fellow (EIPOD-Marie Curie Fellowship), Cell Biology and Biophysics Unit, Structural Biology and Computation Biology Unit, EMBL, Heidelberg, Germany

  • November 2012- April 2013: Research associate , Microbiology and Cell Biology, Indian Institute of Science , Bangalore , India

  • May 2013-present: Assistant Professor, Department of Biological Sciences and Bio Engineering, Indian Institute of Technology, Kanpur, India

  • INSA Medal for Young Scientists Indian National Science Academy, New Delhi

  • M. Sreenivasaya Medal for Best PhD Thesis in Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore.

  • Cancer Research UK Postdoctoral Fellowship

  • EMBO Fellow (European Molecular Biology Organization- Long Term Fellowship)

  • EIPOD-Marie Curie fellowship European Molecular Biology Laboratory (EMBL), Heidelberg, Germany


Lab 1
Chromatin Dynamic Laboratory
Biological Sciences and Bio Engineering
Indian Institute of Technology
Kanpur 208016
Uttar Pradesh, India

Office Phone: 0512-259-4066 / 6428 (O)

Fax: 0512-259-4010

Email: saran[AT]


DNA Repair, Chromatin Remodeling, Actin Related Proteins (ARPs), Mycobacterium tuberculosis, Ustilago maydis



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