Professor, Department of Biological Sciences & Bioengineering (BSBE)
Research Interest
Adult stem cells; biology of germ cells; plant-parasitic nematodes Our laboratory investigates mechanisms that control mitosis-meiosis decision in the free-living nematode Caenorhabditis elegans. Using this system as a paradigm, our ultimate goal is to understand how self-renewal and differentiation decisions are controlled in adult stem cells. We also pursue an RNAi approach to understand the biology of plant-parasitic nematodes to ultimately develop novel pest control strategies.
S. Vaid, M. Ariz, A. Chaturbedi, G. Anil Kumar, and K. Subramaniam 2013. PUF-8 negatively regulates RAS/MAPK signalling to promote differentiation of C. elegans germ cells. Development 140: 1645-1654.
K. Pushpa, G. Anil Kumar, and K. Subramaniam 2013. PUF-8 and TCER-1 are essential for normal levels of several mRNAs in the C. elegans germline. Development 140: 1312-1320.
M. Ariz, M. Rana and K. Subramaniam 2009. C. elegans RNA-binding proteins PUF-8 and MEX-3 function redundantly to promote germline stem cell mitosis. Developmental Biology, 326: 295-304.
S. Jadhav, M. Rana and K. Subramaniam 2008. Multiple maternal proteins coordinate to restrict the translation of C. elegans nanos-2 to primordial germ cells. Development 135: 1803-1812.
B. C. Yadav, K. Veluthambi, and K. Subramaniam 2006. Host-generated double stranded RNA induces RNAi in plant-parasitic nematodes and protects the host from infection. Mol and Biochem Parasit 148: 219-222.
