Professor, Department of Biological Sciences & Bioengineering (BSBE)
Neurobiology of disorders, stress biology, and human molecular genetics
Neurodegenerative disorders are a group of central nervous system dysfunctions characterized by the progressive loss of neural tissues resulting in movement abnormalities, progressive decline in intellectual and cognitive functions, and in certain cases early death. A major research focus of Dr Ganesh's group is to identify and characterize molecular players in neurodegenerative pathways. For this, he conduct genetic screens in affected families and utilize cellular/animal models for testing and validating the hypothesis. Discovery of critical players in neurodegeneration is undoubtedly the first step towards developing effective therapeutics.
Kumar, A, Singh PK, Parihar R, Dwivedi V, Lakhotia SC, and Ganesh S (2014) Decreased O-linked GlcNAcylation protects from cytotoxicity mediated by huntingtin exon1 protein fragment. Journal of Biological Chemistry 289: 13543-13553
Puri R, Suzuki T, Yamakawa K, and Ganesh S. (2012) Dysfunctions in endosomal-lysosomal and autophagy pathways underlie neuropathology in a mouse model for Lafora disease. Human Molecular Genetics 21: 175-184
Sengupta S, Badwar I, Upadhyay M, Singh S and Ganesh S (2011) Malin and laforin are essential components of a protein complex that protects cells from the thermal stress. Journal of Cell Science 124: 2277-2286
Garyali P, Siwach P, Singh PK, Puri R, Mittal S, Sengupta S, Parihar R, and Ganesh S (2009) The laforin-malin complex suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system. Human Molecular Genetics 18, 688-700