The CoE for infectious diseases focuses on technological advancement and the development of diagnostics, therapeutics, and preventive measures. The centre is establishing methods and preventive tools to restrain the spread of infectious diseases, early and accurate diagnosis, and prognosis of infectious diseases. Ongoing research is developing appropriate therapeutics to cure infectious diseases.

Technology Demonstrator Project

Technology Platform for Rapid and Total Eradication of Topical Gram-negative Bacteria via Plasmonic Heating

The project is developing a technology to eradicate gram-negative bacterial cells selectively and efficiently, without affecting host cells. The first step is a non-lethal approach, where bacterial cells will be kept intentionally alive so that the host cells stay safe. This will be done using functionalized plasmonic nanoparticles (PNPs), which will selectively attach to Gram-negative bacterial cells and crosslink them in clusters but will keep them alive. The second step involves a lethal approach, where those PNP-bound bacterial clusters will be laser irradiated to kill all bacterial cells, just like photothermal therapy kills cancer cells. Host cells will remain unaffected.

PI

Name: Dr. Nagma Parveen
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Faculty Members

Dr. Nagma Parveen

Chemistry

Biological nanoparticles, Virus-membrane interactions, Surface functionalization, Binding kinetics, Fluorescence imaging

Dr. Tarun Gupta

Civil Engineering

Instruments for aerosol measurement, Engineering control of particles, atmospheric pollutants, secondary organic aerosol, health assessment of inhaled particles, engine exhaust emissions, and risk assessment.

Associated Faculty Members

Clinical advisors

Dr. Jyotsna Agarwal

Professor & Head, Department of Microbiology
Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow

Microbiology, Molecular Biology, Biotechnology, Infectious Diseases

Patents and publications

• Manorama Dey, Anurag Sharma A.#, Garvita Dhanawat#, Divya Gupta, Krishnan H. Harshan, and Nagma Parveen*, 2024, Synergistic Binding of SARS-CoV-2 to ACE2 and Gangliosides in Native Lipid Membranes, ACS Infectious Diseases, 10, 907-916
• Geetanjali Negi#, Anurag Sharma#, Monika Chaudhary, Divya Gupta, Krishnan H. Harshan, and Nagma Parveen*, 2023, SARS-CoV-2 Binding to Terminal Sialic Acid of Gangliosides Embedded in Lipid Membranes, ACS Infectious Diseases, 9, 1346–1361
• "SARS-CoV-2 Evolved Variants Bind to Sialylated Gangliosides and Inhibited by Tetravalent Sialo-Glycocluster“ Author(s): Negi, Geetanjali; Pandey, Vinay Kumar; Potharaju, Poojitha ; Jaiswal, Manoj; HARSHAN, KRISHNAN; Tiwari, Vinod; Parveen, Nagma. Revision in ACS Infectious Diseases, 2025
• Growth Phase Contribution in Dictating Drug Transport and Subcellular Accumulation inside Escherichia coli. D. Kumar, A. Gayen, Manabendra Chandra*, ACS Infectious Diseases 2024, 10 (9), 3233-3244
• Membrane Permeability Dominates over Electrostatic Interactions in Dictating Drug Transport in Osmotically Shocked Escherichia coli, D. Kumar, A. Gayen, M. Chandra*, The Journal of Physical Chemistry B 2024, 128(20), 4911–4921
• Role of AcrAB-TolC and its components in influx–efflux dynamics of QAC drugs in Escherichia coli revealed using SHG spectroscopy D. Singh, D. Kumar, A. Gayen, M. Chandra* The Journal of Physical Chemistry Letters 2024, 15(31), 7832-7839
• Deciphering the Dilemma of Community Behavior Promotion and Inhibition by Cationic Bactericide-coated Nanoparticles in Gram-Negative Bacteria, Deepak Kumar, Anindita Gayen*, and Manabendra Chandra*, ACS Applied Materials & Interfaces 2025, 17, 15, 22308-22321 (Biological and Medical Applications of Materials and Interfaces)
• A review on potential approach for in silico toxicity analysis of respirable fraction of ambient particulate matter. AD Gupta, T Gupta Environmental Monitoring and Assessment 195 (10), 1216, 2023.
• Influence of ambient particulate matter and environmental factors on the seasonal bioaerosol load in the middle Indo-Gangetic Plain. AD Gupta, V Srivastava, N Yadav, SK Misra, T Gupta Atmospheric Environment, 121081, 2025.
• Growth Phase Contribution in Dictating Drug Transport and Subcellular Accumulation inside Escherichia coli. D. Kumar, A. Gayen, Manabendra Chandra*, ACS Infectious Diseases 2024, 10 (9), 3233-3244
• Membrane Permeability Dominates over Electrostatic Interactions in Dictating Drug Transport in Osmotically Shocked Escherichia coli, D. Kumar, A. Gayen, M. Chandra*, The Journal of Physical Chemistry B 2024, 128(20), 4911–4921
• Role of AcrAB-TolC and its components in influx–efflux dynamics of QAC drugs in Escherichia coli revealed using SHG spectroscopy D. Singh, D. Kumar, A. Gayen, M. Chandra* The Journal of Physical Chemistry Letters 2024, 15(31), 7832-7839
• Deciphering the Dilemma of Community Behavior Promotion and Inhibition by Cationic Bactericide-coated Nanoparticles in Gram-Negative Bacteria, Deepak Kumar, Anindita Gayen*, and Manabendra Chandra*, ACS Applied Materials & Interfaces 2025, 17, 15, 22308-22321 (Biological and Medical Applications of Materials and Interfaces)

Association and Collaboration